Anti-inflammatory effects of orally administered glucosamine oligomer in an experimental model of inflammatory bowel disease

被引：67

作者：

Azuma, Kazuo ^{[1
]}

Osaki, Tomohiro ^{[1
]}

Kurozumi, Seiji ^{[2
]}

Kiyose, Masatoshi ^{[2
]}

Tsuka, Takeshi ^{[1
]}

Murahata, Yusuke ^{[1
]}

Imagawa, Tomohiro ^{[1
]}

Itoh, Norihiko ^{[1
]}

Minami, Saburo ^{[1
]}

Sato, Kimihiko ^{[2
]}

Okamoto, Yoshiharu ^{[1
]}

机构：

[1] Tottori Univ, Sch Vet Med, Dept Vet Clin Med, Tottori 6808553, Japan

[2] Koyo Chem Co Ltd, Chiyoda Ku, Tokyo 1020072, Japan

来源：

CARBOHYDRATE POLYMERS | 2015年 / 115卷

关键词：

Glucosamine oligomers; Inflammatory bowel disease; Anti-inflammatory; Functional food; Nuclear factor-kappa B; SODIUM-INDUCED COLITIS; NF-KAPPA-B; NITRIC-OXIDE; ULCERATIVE-COLITIS; CHITIN NANOFIBRILS; EPITHELIAL-CELLS; MECHANISMS; ANTITUMOR; MICE; CHITOOLIGOSACCHARIDES;

D O I：

10.1016/j.carbpol.2014.09.012

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

Anti-inflammatory effects of oral administration of the glucosamine oligomers (chito-oligosaccharides: COS) were evaluated in an experimental model of inflammatory bowel disease (IBD). Oral administration of COS improved shortening of colon length and tissue injury (as assessed by histology) in mice. Oral administration of COS inhibited inflammation in the colonic mucosa by suppression of myeloperoxidase activation in inflammatory cells, as well as activation of nuclear factor-kappa B, cyclooxygenase-2, and inducible nitric oxide synthase. Oral administration of COS also reduced serum levels of pro-inflammatory cytokines (tumor necrosis factor-alpha and interleukin-6). Moreover, it prolonged survival time in mice. These data suggest that COS have anti-inflammatory effects in an experimental model of IBD, and could be new functional foods for IBD patients. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：448 / 456

页数：9

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