Rapid access to uronic acid-based mimetics of Kdn2en from D-glucurono-6,3-lactone

被引：18

作者：

Florio, P

Thomson, RJ

von Itzstein, M

机构：

[1] Monash Univ, Dept Med Chem, Parkville, Vic 3052, Australia

[2] Griffith Univ, Ctr Biomol Sci & Drug Discovery, Nathan, Qld 9726, Australia

来源：

CARBOHYDRATE RESEARCH | 2000年 / 328卷 / 04期

基金：

澳大利亚研究理事会;

关键词：

Delta(4)-uronic acids; Kdn2en mimetics; thioglycoside;

D O I：

10.1016/S0008-6215(00)00228-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A concise route to novel mimetics of Kdn2en, based on Delta(4)-uronic acids, from D-glucurono-6,3-lactone is presented. Uronic acid-based mimetics in which an aliphatic ether (O-glycoside), a thioether (S-glycoside), or acetamide takes the place of the natural C-6 glycerol sidechain of the sialic acid were synthesized from the key intermediate, methyl 2,3,4-tri-O-acetyl-alpha-D-glucopyranosyluronate bromide. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：445 / 448

页数：4

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