Auxin Perception-Structural Insights

被引：120

作者：

Calderon-Villalobos, Luz Irina ^{[1
]}

Tan, Xu ^{[2
,3
]}

Zheng, Ning ^{[2
]}

Estelle, Mark ^{[1
]}

机构：

[1] Univ Calif San Diego, Sect Cell & Dev Biol, La Jolla, CA 92093 USA

[2] Univ Washington, Sch Med, Dept Pharmacol, Seattle, WA 98195 USA

[3] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Genet,Dept Genet, Boston, MA 02115 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2010年 / 2卷 / 07期

关键词：

SCF UBIQUITIN-LIGASE; FUNCTIONAL GENOMIC ANALYSIS; GENE FAMILY-MEMBERS; BOX PROTEIN TIR1; AUX/IAA PROTEINS; TRANSCRIPTIONAL REPRESSION; ARABIDOPSIS-THALIANA; PLANT DEVELOPMENT; DEGRADATION; PROTEASOME;

D O I：

10.1101/cshperspect.a005546

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The identity of the auxin receptor(s) and the mechanism of auxin perception has been a subject of intense interest since the discovery of auxin almost a century ago. The development of genetic approaches to the study of plant hormone signaling led to the discovery that auxin acts by promoting degradation of transcriptional repressors called Aux/IAA proteins. This process requires a ubiquitin protein ligase (E3) called SCFTIR1 and related SCF complexes. Surprisingly, auxin works by directly binding to TIR1, the F-box protein subunit of this SCF. Structural studies demonstrate that auxin acts like a "molecular glue," to stabilize the interaction between TIR1 and the Aux/IAA substrate. These exciting results solve an old problem in plant biology and reveal new mechanisms for E3 regulation and hormone perception.

引用

页数：16

共 87 条

[41] ARABIDOPSIS AUXIN-RESISTANCE GENE-AXR1 ENCODES A PROTEIN RELATED TO UBIQUITIN-ACTIVATING ENZYME-E1 [J].

LEYSER, HMO ;

LINCOLN, CA ;

TIMPTE, C ;

LAMMER, D ;

TURNER, J ;

ESTELLE, M .

NATURE, 1993, 364 (6433) :161-164

[42] The fall and rise of apical dominance - Commentary [J].

Leyser, O .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2005, 15 (04) :468-471

[43] Dynamic integration of auxin transport and signalling [J].

Leyser, Ottoline .

CURRENT BIOLOGY, 2006, 16 (11) :R424-R433

[44] TOPLESS regulates apical embryonic fate in Arabidopsis [J].

Long, JA ;

Ohno, C ;

Smith, ZR ;

Meyerowitz, EM .

SCIENCE, 2006, 312 (5779) :1520-1523

[45] Promotion of NEDD8-CUL1 conjugate cleavage by COP9 signalosome [J].

Lyapina, S ;

Cope, G ;

Shevchenko, A ;

Serino, G ;

Tsuge, T ;

Zhou, CS ;

Wolf, DA ;

Wei, N ;

Shevchenko, A ;

Deshaies, RJ .

SCIENCE, 2001, 292 (5520) :1382-1385

[46] A critical role of two positively charged amino acids in the Jas motif of Arabidopsis JAZ proteins in mediating coronatine- and jasmonoyl isoleucine-dependent interactions with the COI1F-box protein [J].

Melotto, Maeli ;

Mecey, Christy ;

Niu, Yajie ;

Chung, Hoo Sun ;

Katsir, Leron ;

Yao, Jian ;

Zeng, Weiqing ;

Thines, Bryan ;

Staswick, Paul ;

Browse, John ;

Howe, Gregg A. ;

He, Sheng Yang .

PLANT JOURNAL, 2008, 55 (06) :979-988

[47] Auxin Receptors and Plant Development: A New Signaling Paradigm [J].

Mockaitis, Kelthanne ;

Estelle, Mark .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2008, 24 :55-80

[48] A new CULLIN 1 mutant has altered responses to hormones and light in Arabidopsis [J].

Moon, Jennifer ;

Zhao, Yunde ;

Dai, Xinhua ;

Zhang, Wenjing ;

Gray, William M. ;

Huq, Enamul ;

Estelle, Mark .

PLANT PHYSIOLOGY, 2007, 143 (02) :684-696

[49] Polar auxin transport: controlling where and how much [J].

Muday, GK ;

DeLong, A .

TRENDS IN PLANT SCIENCE, 2001, 6 (11) :535-542

[50] Specificity and similarity of functions of the Aux/IAA genes in auxin signaling of arabidopsis revealed by promoter-exchange experiments among MSG2 IAA19, AXR2/IAA7, and SLR/IAA141 [J].

Muto, Hideki ;

Watahiki, Masaaki K. ;

Nakamoto, Daisuke ;

Kinjo, Masataka ;

Yamamoto, Kotaro T. .

PLANT PHYSIOLOGY, 2007, 144 (01) :187-196

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