A versatile catalyst for the Sonogashira coupling of aryl chlorides

被引：199

作者：

Köllhofer, A ^{[1
]}

Pullmann, T ^{[1
]}

Plenio, H ^{[1
]}

机构：

[1] Tech Univ Darmstadt, Inst Anorgan & Phys Chem, D-64287 Darmstadt, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 09期

关键词：

alkynes; aryl chlorides; cross-coupling; palladium; Sonogashira coupling;

D O I：

10.1002/anie.200390273

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Aryl chlorides are suitable substrates for the Sonogashira coupling! By using the versatile catalyst system Na2[PdCl4]/PR3/ Cul (PR3= (1-Ad)2PBn, PtBu3), the Sonogashira coupling [Eq. (a)] of aryl chlorides with alkynes generates excellent yields of the corresponding disubstituted aryl alkynes.

引用

页码：1056 / +

页数：4

共 45 条

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