Significance of autoantibodies in neonatal lupus erythematosus

被引：21

作者：

Dörner, T

Feist, E

Pruss, A

Chaoui, R

Göldner, B

Hiepe, F

机构：

[1] Humboldt Univ, Dept Med Rheumatol & Clin Immunol, Charite Med Sch, D-10117 Berlin, Germany

[2] Humboldt Univ, Inst Transfus Med, Charite Med Sch, D-10117 Berlin, Germany

[3] Humboldt Univ, Dept Gynecol & Obstet, Charite Med Sch, D-10117 Berlin, Germany

[4] Humboldt Univ, Dept Pediatry Cardiol, Charite Med Sch, D-10117 Berlin, Germany

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 2000年 / 123卷 / 01期

关键词：

autoantibodies; neonatal lupus erythematosus; congenital heart block; systemic lupus erythematosus; Sjogren's syndrome;

D O I：

10.1159/000024424

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Autoantibodies produced by the mother and transported into the fetal circulation are of significant importance in the diagnosis of neonatal lupus syndromes. These humoral autoimmune findings provide an unique opportunity to assess the pathogenic role of autoantibodies against the Ro(SS-A)/La(SS-B) complex, most notably for congenital heart block. Current knowledge about the involved autoantibody-autoantigen systems, including recent therapeutic concepts of these autoimmune syndromes, is summarized. Copyright (C) 2000 S. Karger AG,Basel.

引用

页码：58 / 66

页数：9

共 57 条

[51] CONNECTIVE-TISSUE DISEASE, ANTIBODIES TO RIBONUCLEOPROTEIN, AND CONGENITAL HEART-BLOCK [J].