Effects of a selective agonist and antagonist of CRF2 receptors on cardiovascular function in the rat

被引：28

作者：

Mackay, KB ^{[1
]}

Stiefel, TH ^{[1
]}

Ling, N ^{[1
]}

Foster, AC ^{[1
]}

机构：

[1] Neurocrine Biosci Inc, San Diego, CA 92121 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2003年 / 469卷 / 1-3期

关键词：

CRF (corticotropin-releasing factor); CRF2 receptor antagonist; urocortin; 2; antisauvagine-30; cardiovascular;

D O I：

10.1016/S0014-2999(03)01725-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aim of the present study was to investigate the effects of activation or blockade of the CRF2 receptor subtype on cardiovascular function in conscious rats following systemic i.v. administration of the CRF2 receptor peptide agonist urocortin 2 given alone and the selective CRF2 receptor peptide antagonist antisauvagine-30 given alone. Urocortin 2 caused a dose-dependent reduction in mean arterial blood pressure and a dose-dependent increase in heart rate. Pretreatment with antisauvagine-30 blocked the hypotensive effect of urocortin 2. Antisauvagine-30 failed to produce any statistically significant effects on mean arterial blood pressure and heart rate at doses that completely blocked the effects of urocortin 2. These data verify the cardiovascular effects of selective CRF2 receptor activation, but find no evidence for an endogenous CRF2-mediated tone. (C) 2003 Elsevier Science B.V. All rights reserved.

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收藏

页码：111 / 115

页数：5

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