Chromatin structure in the genomics era

被引：15

作者：

Rando, Oliver J. ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Mol Pharmacol & Biochem, Worcester, MA 01605 USA

来源：

TRENDS IN GENETICS | 2007年 / 23卷 / 02期

关键词：

RNA-POLYMERASE-II; DNA METHYLATION ANALYSIS; VARIANT HISTONE H2A.Z; EMBRYONIC STEM-CELLS; GENE-EXPRESSION; SACCHAROMYCES-CEREVISIAE; DROSOPHILA-MELANOGASTER; EPIGENETIC REGULATION; NUCLEOSOME POSITIONS; ACTIVE CHROMATIN;

D O I：

10.1016/j.tig.2006.12.002

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The packaging of eukaryotic genomes into chromatin has a large influence on DNA-templated processes, such as transcription. The availability of genome sequences and 'genomics' technologies such as DNA microarrays and high-throughput sequencing had an immediate effect on the study of transcriptional regulation, by enabling researchers to identify the coregulation patterns of thousands of genes. These same resources are now being used successfully to study the structure of chromatin. Here, I review some of these new genomics approaches to understanding chromatin structure in eukaryotes.

引用

页码：67 / 73

页数：7

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