Chromatin structure in the genomics era

被引：15

作者：

Rando, Oliver J. ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Mol Pharmacol & Biochem, Worcester, MA 01605 USA

来源：

TRENDS IN GENETICS | 2007年 / 23卷 / 02期

关键词：

RNA-POLYMERASE-II; DNA METHYLATION ANALYSIS; VARIANT HISTONE H2A.Z; EMBRYONIC STEM-CELLS; GENE-EXPRESSION; SACCHAROMYCES-CEREVISIAE; DROSOPHILA-MELANOGASTER; EPIGENETIC REGULATION; NUCLEOSOME POSITIONS; ACTIVE CHROMATIN;

D O I：

10.1016/j.tig.2006.12.002

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The packaging of eukaryotic genomes into chromatin has a large influence on DNA-templated processes, such as transcription. The availability of genome sequences and 'genomics' technologies such as DNA microarrays and high-throughput sequencing had an immediate effect on the study of transcriptional regulation, by enabling researchers to identify the coregulation patterns of thousands of genes. These same resources are now being used successfully to study the structure of chromatin. Here, I review some of these new genomics approaches to understanding chromatin structure in eukaryotes.

引用

页码：67 / 73

页数：7

共 80 条

[31] The Set2 histone methyltransferase functions through the phosphorylated carboxyl-terminal domain of RNA polymerase II [J].

Li, B ;

Howe, L ;

Anderson, S ;

Yates, JR ;

Workman, JL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (11) :8897-8903

[32] Promoter-specific binding of Rap1 revealed by genome-wide maps of protein-DNA association [J].

Lieb, JD ;

Liu, XL ;

Botstein, D ;

Brown, PO .

NATURE GENETICS, 2001, 28 (04) :327-334

[33] Role of transposable elements in heterochromatin and epigenetic control [J].

Lippman, Z ;

Gendrel, AV ;

Black, M ;

Vaughn, MW ;

Dedhia, N ;

McCombie, WR ;

Lavine, K ;

Mittal, V ;

May, B ;

Kasschau, KD ;

Carrington, JC ;

Doerge, RW ;

Colot, V ;

Martienssen, R .

NATURE, 2004, 430 (6998) :471-476

[34] Single-nucleosome mapping of histone modifications in S-cerevisiae [J].

Liu, CL ;

Kaplan, T ;

Kim, M ;

Buratowski, S ;

Schreiber, SL ;

Friedman, N ;

Rando, OJ .

PLOS BIOLOGY, 2005, 3 (10) :1753-1769

[35] Modifying gene expression programs by altering core promoter chromatin architecture [J].

Lomvardas, S ;

Thanos, D .

CELL, 2002, 110 (02) :261-271

[36] Redundant for histone H3 N-terminal lysine residues in subtelomeric gene repression in Saccharomyces cerevisiae [J].

Martin, AM ;

Pouchnik, DJ ;

Walker, JL ;

Wyrick, JJ .

GENETICS, 2004, 167 (03) :1123-1132

[37]

Martinez-Solano Jr, 2004, PROD PRACT QUAL ASSE, V4, P69

[38] Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis [J].

Meissner, A ;

Gnirke, A ;

Bell, GW ;

Ramsahoye, B ;

Lander, ES ;

Jaenisch, R .

NUCLEIC ACIDS RESEARCH, 2005, 33 (18) :5868-5877

[39] Acetylation of H2AZ Lys 14 is associated with genome-wide gene activity in yeast [J].

Millar, CB ;

Xu, F ;

Zhang, KL ;

Grunstein, M .

GENES & DEVELOPMENT, 2006, 20 (06) :711-722

[40] Genome-scale profiling of histone H3.3 replacement patterns [J].

Mito, Y ;

Henikoff, JG ;

Henikoff, S .

NATURE GENETICS, 2005, 37 (10) :1090-1097

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