Enantioselective formation of quaternary centers on β-ketoesters with chiral palladium QUIPHOS catalyst

被引：42

作者：

Brunel, JM ^{[1
]}

Tenaglia, A ^{[1
]}

Buono, G ^{[1
]}

机构：

[1] Fac Sci & Tech St Jerome, CNRS, UMR 6516, Ecole Natl Super Synth Proc & Ingn Chim Aix Marse, F-13397 Marseille 20, France

来源：

TETRAHEDRON-ASYMMETRY | 2000年 / 11卷 / 17期

关键词：

D O I：

10.1016/S0957-4166(00)00337-2

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Asymmetric formation of quaternary centers by allylic alkylation of beta -ketoesters using the chiral palladium QUIPHOS catalyst has been achieved. The results obtained not only depend on the reaction conditions but also on the structural features of both beta -ketoesters and allylating agents. Enantiomeric excesses of up to 95% have been observed. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：3585 / 3590

页数：6

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