Retinoids and nephron mass control

被引:37
作者
Gilbert, T
Merlet-Bénichou, C
机构
[1] Univ Paris 07, INSERM, U319 Dev Normal & Pathol Fonct Epitheliales, F-75251 Paris 05, France
[2] Univ Paris 07, INSERM, U319, F-75005 Paris, France
关键词
vitamin A; nephron number; organogenesis; retinoids; gene expression;
D O I
10.1007/s004670000385
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Advances in the molecular biology of retinoids have provided evidence that vitamin A profoundly influences the differentiation of the whole embryo. In addition to its well-characterized role in primary body axis and central nervous system formation, vitamin A is also required for the ad hoc development of numerous tissues and organs, including the kidney. This review will focus on the emerging evidence that the development of the urogenital tract depends on retinoids. In order to understand the role of vitamin A during kidney development, the mechanisms and sites of retinoic acid production are presented. In addition, an overview of the molecular targets that may be regulated by retinoic acid is included. Together these elements support the concept that control of vitamin A homeostasis during renal organogenesis might control nephrogenesis via specific gene expression. The clinical impact of variations in vitamin A status during Pregnancy is discussed.
引用
收藏
页码:1137 / 1144
页数:8
相关论文
共 77 条
[31]  
HOLLAND PWH, 1988, DEVELOPMENT, V102, P159
[32]  
HSIEHLI HM, 1995, DEVELOPMENT, V121, P1373
[33]   RETINOIC ACID-MEDIATED ACTIVATION OF HNF-3-ALPHA DURING EC STEM-CELL DIFFERENTIATION [J].
JACOB, A ;
BUDHIRAJA, S ;
QIAN, XB ;
CLEVIDENCE, D ;
COSTA, RH ;
REICHEL, RR .
NUCLEIC ACIDS RESEARCH, 1994, 22 (11) :2126-2133
[34]  
Kastner P, 1997, DEVELOPMENT, V124, P313
[35]  
KNITTEL T, 1995, DEVELOPMENT, V121, P1077
[36]  
KRESS C, 1990, DEVELOPMENT, V109, P775
[37]   RETINOIC ACID AND HOMEOBOX GENE-REGULATION [J].
LANGSTON, AW ;
GUDAS, LJ .
CURRENT OPINION IN GENETICS & DEVELOPMENT, 1994, 4 (04) :550-555
[38]  
LAZZARO D, 1992, DEVELOPMENT, V114, P469
[39]   Mild vitamin A deficiency leads to inborn nephron deficit in the rat [J].
Lelièvre-Pégorier, M ;
Vilar, J ;
Ferrier, ML ;
Moreau, E ;
Freund, N ;
Gilbert, T ;
Merlet-Bénichou, C .
KIDNEY INTERNATIONAL, 1998, 54 (05) :1455-1462
[40]   MOUSE RETINOIC ACID RECEPTOR-ALPHA-2 ISOFORM IS TRANSCRIBED FROM A PROMOTER THAT CONTAINS A RETINOIC ACID RESPONSE ELEMENT [J].
LEROY, P ;
NAKSHATRI, H ;
CHAMBON, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (22) :10138-10142