Cytomegalovirus MHC class I homologues and natural killer cells: an overview

被引：15

作者：

Farrell, H ^{[1
]}

Degli-Esposti, M

Densley, E

Cretney, E

Smyth, M

Davis-Poynter, N

机构：

[1] Anim Hlth Trust, Div Virol, Kentford CB8 7UU, Suffolk, England

[2] Univ Western Australia, Dept Microbiol, Nedlands, WA 6907, Australia

[3] Austin Res Inst, Cellular Immun Lab, Heidelberg, Vic 3084, Australia

来源：

MICROBES AND INFECTION | 2000年 / 2卷 / 05期

基金：

英国医学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

cytomegalovirus; immune evasion; MHC class I proteins; NK cells;

D O I：

10.1016/S1286-4579(00)00315-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Viruses that establish a persistent infection with their host have evolved numerous strategies to evade the immune system. Consequently, they are useful tools to dissect the complex cellular processes that comprise the immune response. Rapid progress has been made in recent years in defining the role of cellular MHC class I molecules in regulating the response of natural killer (NK) cells. Concomitantly, the roles of the MHC class I homologues encoded by human and mouse cytomegaloviruses in evading or subverting NK cell responses has received considerable interest. This review discusses the results from a number of studies that have pursued the biological function of the viral MHC class I homologues. Based on the evidence from these studies, hypotheses for the possible role of these intriguing molecules are presented. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

引用

页码：521 / 532

页数：12

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