Trypanocidal activity of a new diterpene from Casearia sylvestris var. lingua

被引：51

作者：

Espindola, LS ^{[1
]}

Vasconcelos, JRE

de Mesquita, ML

Marquié, P

de Paula, JE

Mambu, L

Santana, JM

机构：

[1] Univ Brasilia, Lab Farmacognosia, Fac Ciencias Saude, BR-70910900 Brasilia, DF, Brazil

[2] Inst Biol, Lab Anat Vegetal, Brasilia, DF, Brazil

[3] Univ Brasilia, Lab Multidisciplinar Pesquisa Doenca Chagas, Fac Med, Brasilia, DF, Brazil

[4] Museum Natl Hist Nat, USM 0502, UMR 5154, Paris, France

来源：

PLANTA MEDICA | 2004年 / 70卷 / 11期

关键词：

D O I：

10.1055/s-2004-832655

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioassay-guided fractionation of the hexanic root bark extract of Casearia sylvestris var. lingua led to the isolation of a new clerodane diterpene, whose structure was elucidated as rel-(2S;5R,6R,8S,9S,10R,18S,19R)-19-acetoxy-18,19-epoxy-6-hydro-xy-18-butanoyloxy-2-(2-methylbutanoyloxy)cleroda-3,13(16), 14-triene by spectroscopic means, including 1D and 2D NMR analyses. This compound showed pronounced activity on Trypanosoma cruzi, the casual agent of Chagas' disease, with minimal inhibitory concentration (MIC) at 0.59 mug/mL.

引用

页码：1093 / 1095

页数：3

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