Motor effects of delta 9 THC in cerebellar Lurcher mutant mice

The present study evaluated the effects of the principal active component of marijuana (delta 9 THC) on motor abilities and motor learning in mice with cerebellar dysfunction. For this purpose, spontaneous locomotor activity, equilibrium abilities, muscular tone, motor coordination and motor learning were investigated in Lurcher mutant and non-mutant B6/CBA mice 20 min after i.p. administration of 4 or 8 mg kg(-1) of delta 9 tetra hydro cannabinol (delta 9 THC). The performances were compared to those obtained by Lurcher and non-mutant mice injected with vehicle (Tween 80). The results showed that at the dose of 4 mg kg(-1) but not at the dose of 8 mg kg(-1), the cannabinoid (CB) substance reduced deficits in motor coordination, equilibrium and muscular tone and facilitated motor learning in Lurcher mice. On the other hand, only a muscular strength decrease was observed in control B6/CBA mice injected with the dose of 8 ing kg(-1) of delta 9 THC. These results suggested that cannabinoid derivative could represent a new field of investigation concerning the treatment of cerebellar ataxic syndrome in humans. (c) 2007 Elsevier B.V. All rights reserved.