Recent progress in the biomedical applications of polydopamine nanostructures

Polydopamine is a dark brown-black insoluble biopolymer produced by autoxidation of dopamine. Although its structure and polymerization mechanism have not been fully understood, there has been a rapid growth in the synthesis and applications of polydopamine nanostructures in biomedical fields such as drug delivery, photothermal therapy, bone and tissue engineering, and cell adhesion and patterning, as well as antimicrobial applications. This article is dedicated to reviewing some of the recent polydopamine developments in these biomedical fields. Firstly, the polymerization mechanism is introduced with a discussion of the factors that influence the polymerization process. The discussion is followed by the introduction of various forms of polydopamine nanostructures and their recent applications in biomedical fields, especially in drug delivery. Finally, the review is summarized followed by brief comments on the future prospects of polydopamine.