Tonic excitation and inhibition of neurons: ambient transmitter sources and computational consequences

被引：122

作者：

Cavelier, P ^{[1
]}

Hamann, V ^{[1
]}

Rossi, D ^{[1
]}

Mobbs, P ^{[1
]}

Attwell, D ^{[1
]}

机构：

[1] UCL, Dept Physiol, London WC1E 6BT, England

来源：

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY | 2005年 / 87卷 / 01期

基金：

英国惠康基金;

关键词：

glutamate; GABA; uptake; release; tonic; ambient; extracellular;

D O I：

10.1016/j.pbiomolbio.2004.06.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tonic activation of excitatory and inhibitory receptors, by the ambient concentration of neurotransmitters in the extracellular space of the brain, has been suggested to underlie phenomena as diverse as relapse to cocaine use by reward pathways in the striatum, sparse coding of motor information in the cerebellum, and control of the development of the cerebral and cerebellar cortices. Here we assess the mechanisms which may determine the ambient levels of excitatory and inhibitory neurotransmitters, and consider their likely effect on information processing. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：3 / 16

页数：14

共 93 条

[11] Development of a tonic form of synaptic inhibition in rat cerebellar granule cells resulting from persistent activation of GABA(A) receptors [J].