Self-Adjusting, Polymeric Multilayered Roll that can Keep the Shapes of the Blood Vessel Scaffolds during Biodegradation

被引：149

作者：

Cheng, Shiyu ^{[1
,2
,3
,4
]}

Jin, Yu ^{[1
,2
,5
]}

Wang, Nuoxin ^{[1
,2
]}

Cao, Feng ^{[6
]}

Zhang, Wei ^{[1
,2
]}

Bai, Wei ^{[4
]}

Zheng, Wenfu ^{[1
,2
]}

Jiang, Xingyu ^{[1
,2
,3
]}

机构：

[1] Beijing Engn Res Ctr Bio Nanotechnol, Beijing 100190, Peoples R China

[2] Natl Ctr NanoSci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China

[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[4] Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Peoples R China

[5] Beijing Inst Metrol, Beijing 100029, Peoples R China

[6] Chinese Peoples Liberat Army Gen Hosp, Dept Cardiol, Beijing 100853, Peoples R China

来源：

ADVANCED MATERIALS | 2017年 / 29卷 / 28期

基金：

美国国家科学基金会;

关键词：

blood vessels; PCL; PLGA; self-adjusting; tissue engineering; ENGINEERED VASCULAR GRAFTS; FABRICATION; STRATEGY; FIBERS; CELLS; TECHNOLOGY; TISSUES; TUBES;

D O I：

10.1002/adma.201700171

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A self-adjusting, blood vessel-mimicking, multilayered tubular structure with two polymers, poly(epsilon-caprolactone) (PCL) and poly(dl-lactide-co-glycolide) (PLGA), can keep the shape of the scaffold during biodegradation. The inner (PCL) layer of the tube can expand whereas the outer (PLGA) layers will shrink to maintain the stability of the shape and the inner space of the tubular shape both in vitro and in vivo over months. This approach can be generally useful for making scaffolds that require the maintenance of a defined shape, based on FDA-approved materials.

引用

页数：8

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