Understanding carbohydrate-carbohydrate interactions by means of glyconanotechnology

被引：96

作者：

de la Fuente, JM ^{[1
]}

Penadés, S ^{[1
]}

机构：

[1] CSIC, IIQ, Lab Glyconanotechnol, Grp Carbohidratos, Seville 41092, Spain

来源：

GLYCOCONJUGATE JOURNAL | 2004年 / 21卷 / 3-4期

关键词：

carbohydrate-carbohydrate interaction; Le(X) antigen; glycosphingolipids; glyconanoparticles; self-assembled monolayers; glyconanotechnology;

D O I：

10.1023/B:GLYC.0000044846.80014.cb

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Carbohydrate-carbohydrate interaction is a reliable and versatile mechanism for cell adhesion and recognition. Glycosphingolipid (GSL) clusters at the cell membrane are mainly involved in this interaction. To investigate carbohydrate-carbohydrate interaction an integrated strategy (Glyconanotechnology) was developed. This strategy includes polyvalent tools (gold glyconanoparticles) mimicking GSL clustering at the cell membrane as well as analytical techniques such as AFM, TEM, and SPR to evaluate the interactions. The results obtained by means of this strategy and current status are presented.

引用

页码：149 / 163

页数：15

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