The UK DNA banking network: a "fair access" biobank

被引：31

作者：

Yuille, Martin ^{[1
]}

Dixon, Katherine ^{[1
]}

Platt, Andrew ^{[1
]}

Pullum, Simon ^{[2
]}

Lewis, David ^{[3
]}

Hall, Alistair ^{[4
]}

Ollier, William ^{[1
]}

机构：

[1] Univ Manchester, Ctr Integrated Genom Med Res, Manchester M13 9PT, Lancs, England

[2] Azura Solut Ltd, Martells Barn Offices, Ardleigh CO7 7RU, England

[3] Hlth Protect Agcy, Porton Down SP4 0JG, England

[4] Univ Leeds, Leeds Gen Infirm, Leeds LS1 3EX, W Yorkshire, England

来源：

CELL AND TISSUE BANKING | 2010年 / 11卷 / 03期

基金：

英国医学研究理事会;

关键词：

Research infrastructure; Biobanking; Genetic epidemiology; GENOME-WIDE ASSOCIATION;

D O I：

10.1007/s10561-009-9150-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The UK DNA Banking Network (UDBN) is a secondary biobank: it aggregates and manages resources (samples and data) originated by others. The network comprises, on the one hand, investigator groups led by clinicians each with a distinct disease specialism and, on the other hand, a research infrastructure to manage samples and data. The infrastructure addresses the problem of providing secure quality-assured accrual, storage, replenishment and distribution capacities for samples and of facilitating access to DNA aliquots and data for new peer-reviewed studies in genetic epidemiology. 'Fair access' principles and practices have been pragmatically developed that, unlike open access policies in this area, are not cumbersome but, rather, are fit for the purpose of expediting new study designs and their implementation. UDBN has so far distributed > 60,000 samples for major genotyping studies yielding > 10 billion genotypes. It provides a working model that can inform progress in biobanking nationally, across Europe and internationally.

引用

页码：241 / 251

页数：11

共 8 条

[1] Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls [J].

Burton, Paul R. ;

Clayton, David G. ;

Cardon, Lon R. ;

Craddock, Nick ;

Deloukas, Panos ;

Duncanson, Audrey ;

Kwiatkowski, Dominic P. ;

McCarthy, Mark I. ;

Ouwehand, Willem H. ;

Samani, Nilesh J. ;

Todd, John A. ;

Donnelly, Peter ;

Barrett, Jeffrey C. ;

Davison, Dan ;

Easton, Doug ;

Evans, David ;

Leung, Hin-Tak ;

Marchini, Jonathan L. ;

Morris, Andrew P. ;

Spencer, Chris C. A. ;

Tobin, Martin D. ;

Attwood, Antony P. ;

Boorman, James P. ;

Cant, Barbara ;

Everson, Ursula ;

Hussey, Judith M. ;

Jolley, Jennifer D. ;

Knight, Alexandra S. ;

Koch, Kerstin ;

Meech, Elizabeth ;

Nutland, Sarah ;

Prowse, Christopher V. ;

Stevens, Helen E. ;

Taylor, Niall C. ;

Walters, Graham R. ;

Walker, Neil M. ;

Watkins, Nicholas A. ;

Winzer, Thilo ;

Jones, Richard W. ;

McArdle, Wendy L. ;

Ring, Susan M. ;

Strachan, David P. ;

Pembrey, Marcus ;

Breen, Gerome ;

St Clair, David ;

Caesar, Sian ;

Gordon-Smith, Katherine ;

Jones, Lisa ;

Fraser, Christine ;

Green, Elain K. .

NATURE, 2007, 447 (7145) :661-678

[2] Genome-wide association study identifies novel breast cancer susceptibility loci [J].

Easton, Douglas F. ;

Pooley, Karen A. ;

Dunning, Alison M. ;

Pharoah, Paul D. P. ;

Thompson, Deborah ;

Ballinger, Dennis G. ;

Struewing, Jeffery P. ;

Morrison, Jonathan ;

Field, Helen ;

Luben, Robert ;

Wareham, Nicholas ;

Ahmed, Shahana ;

Healey, Catherine S. ;

Bowman, Richard ;

Meyer, Kerstin B. ;

Haiman, Christopher A. ;

Kolonel, Laurence K. ;

Henderson, Brian E. ;

Le Marchand, Loic ;

Brennan, Paul ;

Sangrajrang, Suleeporn ;

Gaborieau, Valerie ;

Odefrey, Fabrice ;

Shen, Chen-Yang ;

Wu, Pei-Ei ;

Wang, Hui-Chun ;

Eccles, Diana ;

Evans, D. Gareth ;

Peto, Julian ;

Fletcher, Olivia ;

Johnson, Nichola ;

Seal, Sheila ;

Stratton, Michael R. ;

Rahman, Nazneen ;

Chenevix-Trench, Georgia ;

Bojesen, Stig E. ;

Nordestgaard, Borge G. ;

Axelsson, Christen K. ;

Garcia-Closas, Montserrat ;

Brinton, Louise ;

Chanock, Stephen ;

Lissowska, Jolanta ;

Peplonska, Beata ;

Nevanlinna, Heli ;

Fagerholm, Rainer ;

Eerola, Hannaleena ;

Kang, Daehee ;

Yoo, Keun-Young ;

Noh, Dong-Young ;

Ahn, Sei-Hyun .

NATURE, 2007, 447 (7148) :1087-U7

[3]

*ESFRI EUR COMM OF, 2006, EUR ROADM RES INFR

[4] New models of collaboration in genome-wide association studies: the Genetic Association Information Network [J].

Manolio, Teri A. ;

Rodriguez, Laura Lyman ;

Brooks, Lisa ;

Abecasis, Goncalo ;

Ballinger, Dennis ;

Daly, Mark ;

Donnelly, Peter ;

Faraone, Stephen V. ;

Frazer, Kelly ;

Gabriel, Stacey ;

Gejman, Pablo ;

Guttmacher, Alan ;

Harris, Emily L. ;

Insel, Thomas ;

Kelsoe, John R. ;

Lander, Eric ;

McCowin, Norma ;

Mailman, Matthew D. ;

Nabel, Elizabeth ;

Ostell, James ;

Pugh, Elizabeth ;

Sherry, Stephen ;

Sullivan, Patrick F. ;

Thompson, John F. ;

Warram, James ;

Study, GoKinD ;

Wholley, David ;

Milos, Patrice M. ;

Collins, Francis S. .

NATURE GENETICS, 2007, 39 (09) :1045-1051

[5]

*MED RES COUNC, 1999, MRC STRAT PLAN 1999, P13

[6] UK Biobank: from concept to reality [J].

Ollier, W ;

Sprosen, T ;

Peakman, T .

PHARMACOGENOMICS, 2005, 6 (06) :639-646

[7] Genetic Epidemiology 7 - Genetic epidemiology and public health: hope, hype, and future prospects [J].

Smith, GD ;

Ebrahim, S ;

Lewis, S ;

Hansell, AL ;

Palmer, LJ ;

Burton, PR .

LANCET, 2005, 366 (9495) :1484-1498

[8] Biobanking for Europe [J].

Yuille, Martin ;

van Ommen, Gert-Jan ;

Brechot, Christian ;

Cambon-Thomsen, Anne ;

Dagher, Georges ;

Landegren, Ulf ;

Litton, Jan-Eric ;

Pasterk, Markus ;

Peltonen, Leena ;

Taussig, Mike ;

Wichmann, H-Erich ;

Zatloukal, Kurt .

BRIEFINGS IN BIOINFORMATICS, 2008, 9 (01) :14-24

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