The renewed challenge of antibacterial chemotherapy

被引:162
作者
Niccolai, D [1 ]
Tarsi, L [1 ]
Thomas, RJ [1 ]
机构
[1] Glaxo Wellcome SpA, Med Res Ctr, I-37100 Verona, Italy
关键词
D O I
10.1039/a704497f
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
We are currently witnessing a dramatic and alarming increase in the incidence of bacterial infections resistant to most common antibiotics, In this article, we examine briefly the background to this situation, and the mechanisms both of antibacterial action and bacterial resistance, Following this introduction is a discussion of the evolution of the various antibacterial classes and of the current approaches being adopted to keep at bay the threat of a return to a pre-antibiotic era.
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收藏
页码:2333 / 2342
页数:10
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