Experimental Infection of Squirrel Monkeys with Nipah Virus

被引：45

作者：

Marianneau, Philippe ^{[2
]}

Guillaume, Vanessa

Wong, K. Thong ^{[3
]}

Badmanathan, Munisamy ^{[3
]}

Looi, Ren Yih ^{[3
]}

Murri, Severine ^{[2
]}

Loth, Philippe ^{[2
]}

Tordo, Noel ^{[2
]}

Wild, T. Fabian

Horvat, Branka ^{[1
]}

Contamin, Hugues ^{[2
]}

机构：

[1] INSERM, U758, F-69007 Lyon, France

[2] Inst Pasteur, Lyon, France

[3] Univ Malaya, Kuala Lumpur, Malaysia

来源：

EMERGING INFECTIOUS DISEASES | 2010年 / 16卷 / 03期

关键词：

HAMSTER MODEL; MALAYSIA; TRANSMISSION; ENCEPHALITIS; PROTECTION; BANGLADESH; OUTBREAK;

D O I：

10.3201/eid1603.091346

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

We infected squirrel monkeys (Saimiri sciureus) with Nipah virus to determine the monkeys' suitability for use as primate models in preclinical testing of preventive and therapeutic treatments. Infection of squirrel monkeys through intravenous infection was followed by high death rates associated with acute neurologic and respiratory illness and viral RNA and antigen production.

引用

收藏

页码：507 / 510

页数：4

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