Enabling Technologies for the Future of Chemical Synthesis

被引:133
作者
Fitzpatrick, Daniel E. [1 ]
Battilocchio, Claudio [1 ]
Ley, Steven V. [1 ]
机构
[1] Univ Cambridge, Dept Chem, Innovat Technol Ctr, Lensfield Rd, Cambridge CB2 1EW, England
基金
英国工程与自然科学研究理事会;
关键词
FRONTAL AFFINITY-CHROMATOGRAPHY; GENERATED DIAZO-COMPOUNDS; CONTINUOUS-FLOW CHEMISTRY; ORGANIC-SYNTHESIS; PROCESS INTENSIFICATION; MULTISTEP SYNTHESIS; PROCESS WINDOWS; DISCOVERY TOOL; OPTIMIZATION; PLATFORM;
D O I
10.1021/acscentsci.6b00015
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Technology is evolving at breakneck pace, changing the way we communicate, travel, find out information, and live our lives. Yet chemistry as a science has been slower to adapt to this rapidly shifting world. In this Outlook we use highlights from recent literature reports to describe how progresses in enabling technologies are altering this trend, permitting chemists to incorporate new advances into their work at all levels of the chemistry development cycle. We discuss the benefits and challenges that have arisen, impacts on academic-industry relationships, and future trends in the area of chemical synthesis.
引用
收藏
页码:131 / 138
页数:8
相关论文
共 61 条
[1]  
Anastas P., 1998, GREEN CHEM THEORY PR
[2]  
Battilocchio C, 2016, NAT CHEM, V8, P360, DOI [10.1038/NCHEM.2439, 10.1038/nchem.2439]
[3]   Mild and Selective Heterogeneous Catalytic Hydration of Nitriles to Amides by Flowing through Manganese Dioxide [J].
Battilocchio, Claudio ;
Hawkins, Joel M. ;
Ley, Steven V. .
ORGANIC LETTERS, 2014, 16 (04) :1060-1063
[4]   A Mild and Efficient Flow Procedure for the Transfer Hydrogenation of Ketones and Aldehydes using Hydrous Zirconia [J].
Battilocchio, Claudio ;
Hawkins, Joel M. ;
Ley, Steven V. .
ORGANIC LETTERS, 2013, 15 (09) :2278-2281
[5]   The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry [J].
Baumann, Marcus ;
Baxendale, Ian R. .
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 2015, 11 :1194-1219
[6]   A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: a new paradigm for molecular assembly [J].
Baxendale, Ian R. ;
Deeley, Jon ;
Griffiths-Jones, Charlotte M. ;
Ley, Steven V. ;
Saaby, Steen ;
Tranmer, Geoffrey K. .
CHEMICAL COMMUNICATIONS, 2006, (24) :2566-2568
[7]   Preparation of the neolignan natural product grossamide by a continuous-flow process [J].
Baxendale, IR ;
Griffiths-Jones, CM ;
Ley, SV ;
Tranmer, GK .
SYNLETT, 2006, (03) :427-430
[8]   Kinetic Profiling of Catalytic Organic Reactions as a Mechanistic Tool [J].
Blackmond, Donna G. .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2015, 137 (34) :10852-10866
[9]   Sustainable Flow Oppenauer Oxidation of Secondary Benzylic Alcohols with a Heterogeneous Zirconia Catalyst [J].
Chorghade, Rajeev ;
Battilocchio, Claudio ;
Hawkins, Joel M. ;
Ley, Steven V. .
ORGANIC LETTERS, 2013, 15 (22) :5698-5701
[10]   Computational Study and Kinetic Analysis of the Aminolysis of Thiolactones [J].
Desmet, Gilles B. ;
D'hooge, Dagmar R. ;
Sabbe, Maarten K. ;
Marin, Guy B. ;
Du Prez, Filip E. ;
Espeel, Pieter ;
Reyniers, Marie-Francoise .
JOURNAL OF ORGANIC CHEMISTRY, 2015, 80 (17) :8520-8529