Immunopathological factors for vertical transmission of HIV-1

被引：3

作者：

Edgeworth, RL ^{[1
]}

Ugen, KE ^{[1
]}

机构：

[1] Univ S Florida, Coll Med, Dept Med Microbiol & Immunol, Tampa, FL 33612 USA

来源：

PATHOBIOLOGY | 2000年 / 68卷 / 02期

关键词：

HIV-1; AIDS; vertical transmission; maternal humoral immune responses;

D O I：

10.1159/000028115

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

With the global rise in human immunodeficiency virus-1 (HIV-1) infection in women of childbearing age, there has also been an alarming rise in the number of mother-to-child transmissions of HIV-1. Although drug therapies such as zidovudine as well as nevirapine have been demonstrated to significantly decrease the incidence of vertical transmission of HIV-1, these therapeutic regimens a re still not widely available in some developing countries where maternal-to-child transmission of HIV-1 continues to occur at an alarming rate. Therefore, the continued studies of mechanisms and correlates of vertical transmission of HIV-1 are warranted. The current status of immunological and virological correlates of vertical transmission are summarized in this review. In addition, information concerning recent therapeutic agents for the prevention of HIV-1 vertical transmission is presented, Copyright (C) 2000 S. Karger AG, Basel.

引用

页码：53 / 67

页数：15

共 140 条

[1] The mode of delivery and the risk of vertical transmission of human immunodeficiency virus type 1 -: A meta-analysis of 15 prospective cohort studies [J].

Andiman, W ;

Boucher, M ;

Burns, D ;

Bryson, Y ;

Farley, J ;

Fowler, H ;

Gabiano, C ;

Galli, L ;

Hutto, C ;

Kind, C ;

Korber, B ;

Kovacs, A ;

Krogstad, P ;

Landesman, S ;

Lapointe, N ;

Lemay, M ;

Lew, J ;

Mandelbrot, L ;

Mayaux, MJ ;

Mellins, R ;

Minkoff, H ;

Mofenson, L ;

Nielsen, K ;

Newell, ML ;

Pardi, G ;

Peavy, H ;

Peckham, C ;

Read, J ;

Rother, C ;

Rudin, C ;

Scott, G ;

Semprini, A ;

Shearer, W ;

Simonds, R ;

Simpson, B ;

Stek, A ;

Tovo, PA ;

Tuomala, R ;

Van Dyke, R ;

Weedon, J ;

de Martino, M ;

Lindsay, M ;

Belair, S ;

Chan, L ;

Harris, D ;

Kalish, L ;

Muenz, L ;

Nugent, R ;

Schluchter, M ;

Durako, S .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 340 (13) :977-987

[2]

[Anonymous], 1998, MMWR Recomm Rep, V47, P1

[3] Safety and immunogenicity of HIV-1 DNA constructs in chimpanzees [J].

Bagarazzi, ML ;

Boyer, JD ;

Ugen, KE ;

Javadian, MA ;

Chattergoon, M ;

Shah, A ;

Bennett, M ;

Ciccarelli, R ;

Carrano, R ;

Coney, L ;

Weiner, DB .

VACCINE, 1998, 16 (19) :1836-1841

[4] CCR5, vertical transmission of HIV-1, and disease progression [J].

Bailey, AJ ;

Newell, ML ;

De Rossi, A ;

Giaquinto, C ;

Iasci, A ;

Ravizza, M ;

Garcia-Rodriguez, MC .

JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY, 1999, 20 (02) :211-212

[5] Homozygous Delta 32 deletion of the CCR-5 chemokine receptor gene in an HIV-1-infected patient [J].

Balotta, C ;

Bagnarelli, P ;

Violin, M ;

Ridolfo, AL ;

Zhou, D ;

Berlusconi, A ;

Corvasce, S ;

Corbellino, M ;

Clementi, M ;

Clerici, M ;

Moroni, M ;

Galli, M .

AIDS, 1997, 11 (10) :F67-F71

[6]

Bawdon R E, 1998, Infect Dis Obstet Gynecol, V6, P244, DOI 10.1002/(SICI)1098-0997(1998)6:6<244::AID-IDOG4>3.0.CO

[7]

2-B

[8] The maternal-fetal transfer of lamivudine in the ex vivo human placenta [J].

Bloom, SL ;

Dias, KM ;

Bawdon, RE ;

Gilstrap, LC .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1997, 176 (02) :291-293

[9] CORRELATION OF PERINATAL TRANSMISSION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 WITH MATERNAL VIREMIA AND LYMPHOCYTE PHENOTYPES [J].

BORKOWSKY, W ;

KRASINSKI, K ;

CAO, YZ ;

HO, D ;

POLLACK, H ;

MOORE, T ;

CHEN, SH ;

ALLEN, M ;

TAO, PT .

JOURNAL OF PEDIATRICS, 1994, 125 (03) :345-351

[10] CLEARANCE OF HIV-INFECTION IN A PERINATALLY INFECTED INFANT [J].

BRYSON, YJ ;

PANG, S ;

WEI, LS ;

DICKOVER, R ;

DIAGNE, A ;

CHEN, ISY .

NEW ENGLAND JOURNAL OF MEDICINE, 1995, 332 (13) :833-838

← 1 2 3 4 5 6 7 8 9 10 →