Immunopathological factors for vertical transmission of HIV-1

被引：3

作者：

Edgeworth, RL ^{[1
]}

Ugen, KE ^{[1
]}

机构：

[1] Univ S Florida, Coll Med, Dept Med Microbiol & Immunol, Tampa, FL 33612 USA

来源：

PATHOBIOLOGY | 2000年 / 68卷 / 02期

关键词：

HIV-1; AIDS; vertical transmission; maternal humoral immune responses;

D O I：

10.1159/000028115

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

With the global rise in human immunodeficiency virus-1 (HIV-1) infection in women of childbearing age, there has also been an alarming rise in the number of mother-to-child transmissions of HIV-1. Although drug therapies such as zidovudine as well as nevirapine have been demonstrated to significantly decrease the incidence of vertical transmission of HIV-1, these therapeutic regimens a re still not widely available in some developing countries where maternal-to-child transmission of HIV-1 continues to occur at an alarming rate. Therefore, the continued studies of mechanisms and correlates of vertical transmission of HIV-1 are warranted. The current status of immunological and virological correlates of vertical transmission are summarized in this review. In addition, information concerning recent therapeutic agents for the prevention of HIV-1 vertical transmission is presented, Copyright (C) 2000 S. Karger AG, Basel.

引用

页码：53 / 67

页数：15

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