HIV Persistence and the Prospect of Long-Term Drug-Free Remissions for HIV-Infected Individuals

被引：232

作者：

Trono, Didier ^{[1
,2
]}

Van Lint, Carine ^{[3
]}

Rouzioux, Christine ^{[4
]}

Verdin, Eric ^{[5
]}

Barre-Sinoussi, Francoise ^{[6
]}

Chun, Tae-Wook ^{[7
]}

Chomont, Nicolas ^{[8
]}

机构：

[1] Ecole Polytech Fed Lausanne, Sch Life Sci, CH-1015 Lausanne, Switzerland

[2] Ecole Polytech Fed Lausanne, Frontiers in Genet Program, CH-1015 Lausanne, Switzerland

[3] Univ Libre Bruxelles, IBMM, B-6041 Gosselies, Belgium

[4] Univ Paris 05, CHU Necker, F-75743 Paris, France

[5] Gladstone Inst Virol & Immunol, San Francisco, CA 94158 USA

[6] Inst Pasteur, Dept Virol, Unit Regulat Retroviral Infect, F-75015 Paris, France

[7] NIAID, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA

[8] Vaccine & Gene Therapy Inst Florida, Port St Lucie, FL 34987 USA

来源：

SCIENCE | 2010年 / 329卷 / 5988期

基金：

美国国家卫生研究院; 瑞士国家科学基金会;

关键词：

CD4(+) T-CELLS; ACTIVE ANTIRETROVIRAL THERAPY; RALTEGRAVIR INTENSIFICATION; DISEASE PROGRESSION; CELLULAR RESERVOIRS; ANTIVIRAL THERAPY; EXTENDED PERIODS; LATENT RESERVOIR; VIRUS-INFECTIONS; VALPROIC ACID;

D O I：

10.1126/science.1191047

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

HIV infection can persist in spite of efficacious antiretroviral therapies. Although incomplete inhibition of viral replication may contribute to this phenomenon, this is largely due to the early establishment of a stable reservoir of latently infected cells. Thus, life-long antiviral therapy may be needed to control HIV. Such therapy is prone to drug resistance and cumulative side effects and is an unbearable financial burden for regions of the world hit hardest by the epidemic. This review discusses our current understanding of HIV persistence and the limitations of potential approaches to eradicate the virus and accordingly pleads for a joint multidisciplinary effort toward two highly related goals: the development of an HIV prophylactic vaccine and the achievement of long-term drug-free remissions in HIV-infected individuals.

引用

页码：174 / 180

页数：7

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