Apoptosis and pathogenesis of avian influenza A (H5N1) virus in humans

被引：137

作者：

Uiprasertkui, Mongkol

Kitphati, Rungrueng

Piuthavathana, Pilaipan

Kriwong, Romchat

Kongchanagul, Alita

Ungchusak, Kumnuan

Angkasekwinai, Suwimon

Chokephaibulkit, Kulkanya

Srisook, Kanittar

Vanprapar, Nirun

Auewarakul, Prasert ^{[1
]}

机构：

[1] Mahidol Univ, Fac Med, Siriraj Hosp, Dept Microbiol, Bangkok 10700, Thailand

[2] Minist Publ Hlth, Bangkok, Thailand

[3] Phaholpolphayuhasena Hosp, Kanjanaburi, Thailand

来源：

EMERGING INFECTIOUS DISEASES | 2007年 / 13卷 / 05期

关键词：

D O I：

10.3201/eid1305.060572

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The pathogenesis of avian influenza A (H5N1) virus in humans has not been clearly elucidated. Apoptosis may also play an important role. We studied autopsy specimens from 2 patients who died of infection with this virus. Apoptosis was observed in alveolar epithelial cells, which is the major target cell type for the viral replication. Numerous apoptotic leukocytes were observed in the lung of a patient who died on day 6 of illness. Our data suggest that apoptosis may play a major role in the pathogenesis of influenza (H5N1) virus in humans by destroying alveolar epithelial cells. This pathogenesis causes pneumonia and destroys leukocytes, leading to leukopenia, which is a prominent clinical feature of influenza (H5N1) virus in humans. Whether observed apoptotic cells were a direct result of the viral replication or a consequence of an overactivation of the immune system requires further studies.

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页码：708 / 712

页数：5

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