The centrosome in higher organisms: Structure, composition, and duplication

被引：43

作者：

Ou, Y ^{[1
]}

Rattner, JB ^{[1
]}

机构：

[1] Univ Calgary, Dept Cell Biol & Anat, Calgary, AB T2N 1N4, Canada

来源：

INTERNATIONAL REVIEW OF CYTOLOGY - A SURVEY OF CELL BIOLOGY, VOL. 238 | 2004年 / 238卷

基金：

加拿大健康研究院; 加拿大自然科学与工程研究理事会;

关键词：

centriole; pericentriolar material; PCM; centrosome; centrosome duplication; centrosome structure; centrosome function;

D O I：

10.1016/S0074-7696(04)38003-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The centrosome found in higher organisms is an organelle with a complex and dynamic architecture and composition. This organelle not only functions as a microtubule-organizing center, but also is integrated with or impacts a number of cellular processes. Defects associated with this organelle have been linked to a variety of human diseases including several forms of cancer. Here we review the emerging picture of how the structure, composition, duplication, and function of the centrosome found in higher organisms are interrelated.

引用

页码：119 / +

页数：69

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