Megalin-mediated endocytosis in renal proximal tubule

被引：48

作者：

Christensen, EI ^{[1
]}

Birn, H ^{[1
]}

Verroust, P ^{[1
]}

Moestrup, SK ^{[1
]}

机构：

[1] Univ Aarhus, Inst Anat, Dept Cell Biol, Aarhus C, Denmark

来源：

RENAL FAILURE | 1998年 / 20卷 / 02期

关键词：

megalin; kidney; proximal tubule;

D O I：

10.3109/08860229809045102

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Megalin a 600 kDa membrane protein belonging to the IDL receptor family is highly expressed in the endocytic pathway of renal proximal tubules. In addition, this receptor is found in several other epithelia facing transcellular fluids but is also expressed in the parathyroid glands. Recent studies have established this protein as probably the most important receptor for endocytosis of macromolecules filtered in the renal glomeruli. The ligands reported to bind to megalin consist of a variety of different substances including albumin, vitamin-carrier complexes, proteinases and proteinase-inhibitor complexes, lipoprotein particles, receptor associated protein (RAP), different drugs and calcium.

引用

页码：191 / 199

页数：9

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