Synthesis of novel and uniquely shaped 3-azabicyclo[4.2.0]octan-4-one derivatives by sequential Ugi/[2+2] ene-enone photocycloadditions

被引：32

作者：

Akritopoulou-Zanze, Irini ^{[1
]}

Whitehead, Alan ^{[1
]}

Waters, Jan E. ^{[1
]}

Henry, Rodger F. ^{[1
]}

Djuric, Stevan W. ^{[1
]}

机构：

[1] Abbott Labs, Scaffold Oriented Synth & Struct Chem, Abbott Pk, IL 60064 USA

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 07期

关键词：

MULTICOMPONENT REACTIONS; UGI REACTION; ISOCYANIDE; ACCESS;

D O I：

10.1021/ol070164l

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report a new methodology for the construction of novel and uniquely shaped 3-azabicyclo[4.2.0]octan-4-one derivatives by combining the Ugi multicomponent reaction with [2+2] enone-olefin photochemical transformations. The overall sequence is capable of creating up to five stereocenters; however, in most cases, only two diastereomers are observed.

引用

页码：1299 / 1302

页数：4

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