Nucleation of β-hairpin structure in a pyrrole amino acid containing peptide

被引：10

作者：

Chakraborty, TK ^{[1
]}

Mohan, BK ^{[1
]}

Kumar, SK ^{[1
]}

Kunwar, AC ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 03期

关键词：

peptide mimetics; pyrrole amino acid; hydrogen bonding; conformation; NMR;

D O I：

10.1016/S0040-4039(02)02593-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis and conformational studies of two short peptides containing pyrrole amino acids (1, Paa), Boc-Paa-Paa-DPro-Gly-Xaa-Paa-Paa-OMe (2: Xaa=Ala; 3: Xaa=Val), were carried out in which it was established that replacement of Ala in 2 with a Val residue helps peptide 3 to adopt a well-defined beta-hairpin conformation in a nonpolar solvent, like CDCl3. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：471 / 473

页数：3

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