Synthesis of meiosis-activating sterols containing fluorine

被引：5

作者：

Wenckens, M

Gronvald, F

Hansen, JB ^{[1
]}

机构：

[1] Novo Nordisk AS, Med Chem Res, DK-2760 Malov, Denmark

[2] Roskilde Univ Ctr, Dept Chem & Life Sci, DK-4000 Roskilde, Denmark

来源：

ACTA CHEMICA SCANDINAVICA | 1998年 / 52卷 / 04期

关键词：

D O I：

10.3891/acta.chem.scand.52-0503

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is documented that specific types of sterol play a major role in the resumption of meiosis in oocytes from mice in vitro. 4,4-Dimethyl-5 alpha-cholesta-8,14,24-trien-3 beta-ol (FF-MAS) isolated from human follicular fluid and 4,4-dimethyl-5 alpha-cholesta-8,24-dien-3 beta-ol (T-MAS) isolated from bull testicular tissue, have been shown to activate (promote) meiosis in vitro. In order to evaluate the biological activity and stability of such compounds, new demethylsterol derivatives have been synthesised. Using diethylaminosulfur trifluoride (DAST) it was possible to synthesise selected Delta(8), Delta(14) sterols with mono and difluoro substitution at C3.

引用

页码：503 / 507

页数：5

共 21 条

[1] Chemical consequences of long-range orbital interactions in cholestane-3,7-diol monosulfonate esters. A seven-center fragmentation [J].