Carbon-carbon bond construction on solid support: triethylborane-induced radical reactions of oxime ethers

被引:32
作者
Miyabe, H [1 ]
Nishimura, A [1 ]
Fujishima, Y [1 ]
Naito, T [1 ]
机构
[1] Kobe Pharmaceut Univ, Kobe, Hyogo 6588558, Japan
关键词
radical reactions; solid-phase reactions; amino acids; oxime ethers;
D O I
10.1016/S0040-4020(03)00154-6
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The triethylborane-induced solid-phase radical reaction was studied. The solid-phase radical reaction of oxime ether anchored to Wang resin proceeded smoothly to give the alpha-amino acid derivatives. The carbon-carbon bond-forming radical reaction of TentaGel OH resin-bound glyoxylic oxime ether proceeded even in aqueous media. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:1901 / 1907
页数:7
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