Recent Advances in Biosensors for Detecting Cancer-Derived Exosomes

被引：205

作者：

Cheng, Nan ^{[1
,2
]}

Du, Dan ^{[2
]}

Wang, Xinxian ^{[1
]}

Liu, Dong ^{[2
]}

Xu, Wentao ^{[1
]}

Luo, Yunbo ^{[1
]}

Lin, Yuehe ^{[2
]}

机构：

[1] China Agr Univ, Coll Food Sci & Nutr Engn, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Beijing 100083, Peoples R China

[2] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA

来源：

TRENDS IN BIOTECHNOLOGY | 2019年 / 37卷 / 11期

基金：

中国博士后科学基金;

关键词：

PANCREATIC-CANCER; ELECTROCHEMICAL DETECTION; DNA; APTASENSOR; BIOMARKER; QUANTIFICATION; AMPLIFICATION; IMMUNOASSAY; NANOSHEETS;

D O I：

10.1016/j.tibtech.2019.04.008

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Early detection and effective treatments are two of the greatest challenges in the fight against cancer. Cancer-derived exosomes are attractive biomarkers for the early diagnosis and therapeutic response evaluation of cancer. Here, we review recent advances in biosensors for the detection of cancer-derived exosomes. We discuss the potential exosomal biomarkers of various cancers, which can be applied as indicative targets in the design of biosensors. We further describe the fabrication of exosome detection biosensors with respect to biological recognition strategies and signal transduction techniques, which involve integrated scientific and technological aspects of analytical chemistry and nanotechnology. Furthermore, future research directions and challenges in using cancer-derived exosomes for point-of-care (POC) testing are presented.

引用

页码：1236 / 1254

页数：19

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