Meiotic roles of Mec1, a budding yeast homolog of mammalian ATR/ATM

被引：31

作者：

Carballo, Jess A. ^{[1
]}

Cha, Rita S. ^{[1
]}

机构：

[1] Natl Inst Med Res, Div Stem Cell Biol & Dev Genet, MRC, London NW7 1AA, England

来源：

CHROMOSOME RESEARCH | 2007年 / 15卷 / 05期

基金：

英国医学研究理事会;

关键词：

chromosome synapsis; Mec; 1; meiosis; meiotic progression; meiotic recombination;

D O I：

10.1007/s10577-007-1145-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Budding yeast Mec1, a homolog of mammalian ATR/ATM, is C an essential chromosome-based signal transduction protein. Mec1 is a key checkpoint regulator and plays a critical role in the maintenance of genome stability. Mec1 is also required for meiosis; loss of Mec1 functions leads to a number of meiotic defects includina reduction in recombination, loss of inter-homolog bias, loss of crossover control, and failure in meiotic progression. Here we review currently available data on meiotic defects associated with loss of Mec1 functions and discuss the possibility that Mec1 may participate as a fundamentally positive player in coordinating and promoting basic meiotic chromosomal processes during nonnal meiosis.

引用

页码：539 / 550

页数：12

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