Diastereoselective synthesis of 2-oxiranyl and 2-aziridinyl thiazoles

被引：12

作者：

Bona, F

De Vitis, L

Florio, S

Ronzini, L

Troisi, L

机构：

[1] Univ Lecce, Dipartimento Sci & Technol Biol & Ambientali, I-73100 Lecce, Italy

[2] Univ Bari, CNR, Dipartimento Farmaco Chim, Ist Chim Composti Organaomet, I-70125 Bari, Italy

来源：

TETRAHEDRON | 2003年 / 59卷 / 09期

关键词：

thiazolylalkyloxiranes; thiazolylalkylaziridines; carbanion; nucleophilic addition;

D O I：

10.1016/S0040-4020(03)00105-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Chloroalkylthiazolyllithiums, prepared by deprotonating the 2-chloroalkylthiazoles with n-BuLi at -78degreesC in THF, add to ketones or imines affording in 'one-pot' oxiranes and aziridines in a Z stereoselective manner. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：1381 / 1387

页数：7

共 23 条

[1] AN EFFICIENT SYNTHESIS OF 2-(HALOGENOMETHYL)PENEMS [J].