Cys-tRNACys formation and cysteine biosynthesis in methanogenic archaea:: two faces of the same problem?

被引：8

作者：

Ambrogelly, A ^{[1
]}

Kamtekar, S ^{[1
]}

Sauerwald, A ^{[1
]}

Ruan, B ^{[1
]}

Tumbula-Hansen, D ^{[1
]}

Kennedy, D ^{[1
]}

Ahel, I ^{[1
]}

Söll, D ^{[1
]}

机构：

[1] Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT 06504 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2004年 / 61卷 / 19-20期

关键词：

Cys-tRNA(Cys); cysteine biosynthesis; cysteinyl-tRNA synthetase; archaea; methanogens;

D O I：

10.1007/s00018-004-4194-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aminoacyl-tRNA ( transfer RNA) synthetases are essential components of the cellular translation machinery as they provide the ribosome with aminoacyl-tRNAs. Aminoacyl-tRNA synthesis is generally well understood. However, the mechanism of Cys-tRNACys formation in three methanogenic archaea (Methanocaldococcus jannaschii, Methanothermobacter thermautotrophicus and Methanopyrus kandleri) is still unknown, since no recognizable gene for a canonical cysteinyl-tRNA synthetase could be identified in the genome sequences of these organisms. Here we review the different routes recently proposed for Cys-tRNA(Cys) formation and discuss its possible link with cysteine biosynthesis in these methanogenic archaea.

引用

页码：2437 / 2445

页数：9

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