Utilizing RNA interference to enhance cancer drug discovery

被引：209

作者：

Iorns, Elizabeth ^{[1
]}

Lord, Christopher J. ^{[1
]}

Turner, Nicholas ^{[1
]}

Ashworth, Alan ^{[1
]}

机构：

[1] Inst Canc Res, Breakthrough Breast Canc Res Ctr, London SW3 6JB, England

来源：

NATURE REVIEWS DRUG DISCOVERY | 2007年 / 6卷 / 07期

关键词：

D O I：

10.1038/nrd2355

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

With the development of RNA interference (RNAi) libraries, systematic and cost-effective genome-wide loss-of-function screens can now be carried out with the aim of assessing the role of specific genes in neoplastic phenotypes, and the rapid identification of novel drug targets. Here, we discuss the existing applications of RNAi in cancer drug discovery and highlight areas in this process that may benefit from this technology in the future.

引用

页码：556 / 568

页数：13

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