A G protein-coupled receptor is a plasma membrane receptor for the plant hormone abscisic acid

被引：157

作者：

Liu, Xigang

Yue, Yanling

Li, Bin

Nie, Yanli

Li, Wei

Wu, Wei-Hua

Ma, Ligeng

机构：

[1] Natl Inst Biol Sci, Beijing 102206, Peoples R China

[2] Hebei Normal Univ, Mol & Cellular Biol Lab, Shiziazhuang 050016, Hebei, Peoples R China

[3] China Agr Univ, State Key Lab Plant Physiol & Biochem, Coll Biol Sci, Beijing 100094, Peoples R China

来源：

SCIENCE | 2007年 / 315卷 / 5819期

关键词：

D O I：

10.1126/science.1135882

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The plant hormone abscisic acid (ABA) regulates many physiological and developmental processes in plants. The mechanism of ABA perception at the cell surface is not understood. Here, we report that a G protein-coupled receptor genetically and physically interacts with the G protein a subunit GPA1 to mediate all known ABA responses in Arabidopsis. Overexpressing this receptor results in an ABA-hypersensitive phenotype. This receptor binds ABA with high affinity at physiological concentration with expected kinetics and stereospecificity. The binding of ABA to the receptor leads to the dissociation of the receptor-GPA1 complex in yeast. Our results demonstrate that this G protein-coupled receptor is a plasma membrane ABA receptor.

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页码：1712 / 1716

页数：5

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