Identification and analysis of cis-regulatory elements in development using comparative genomics with the pufferfish, Fugu rubripes

被引：6

作者：

Elgar, G ^{[1
]}

机构：

[1] MRC, Rosalind Franklin Ctr Genom Res, Hinxton CB10 1SB, Cambs, England

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2004年 / 15卷 / 06期

关键词：

pufferfish; Fugu rubripes; comparative vertebrate genomics; development; conserved non-coding sequence;

D O I：

10.1016/j.semcdb.2004.10.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The control of vertebrate development is facilitated by cis-regulatory sequences hardwired into the genome. Given that many developmental processes are strikingly similar across all backboned animals, it is reasonable to expect these sequences to be conserved at the nucleotide level, their potential for mutation being constrained by their function. Comparison between the genomes of highly divergent organisms allows such sequences to be identified and some of the most successful approaches have compared regions from the pufferfish, Fugu rubripes, with its distant mammalian relatives, rodents and humans. This review describes progress made in this kind of comparison, from small regions of individual genes, to whole genome alignments. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：715 / 719

页数：5

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