Anti-inflammatory and analgesic activity of Bouchea fluminensis

被引:21
作者
Costa, VB
Coube, CS
Marinho, BG
Matheus, ME
Leitao, SG
Fernandes, PD [1 ]
机构
[1] Univ Fed Rio de Janeiro, ICB, Dept Farmacol, Rio De Janeiro, Brazil
[2] Univ Fed Rio de Janeiro, Fac Farm, Dept Prod Nat & Alimentos, Rio De Janeiro, Brazil
关键词
Bouchea fluminensis; analgesic effect; anti-inflammatory effect; ursolic acid; oleanolic acid; micromeric acid;
D O I
10.1016/S0367-326X(03)00049-2
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Dried leaves extract from Bouchea fluminensis was assessed in anti-inflammatory (mouse paw edema) and analgesic models (acetic acid-induced writhings and hot plate). Oral pretreatment of animals with a crude mixture (IG) and a purified mixture of ursolic, oleanolic and micromeric acids (IG-59) at doses ranging from 1 to 30 mg/kg, significantly inhibited carrageenin-induced edema formation. At the same doses, IG and IG-59 also exhibited peripheral and central analgesic activity. It seems that B. fluminensis triterpenes develop their analgesic effect through central opioid receptors, due to the observation that naloxone reverted analgesic activity on the hot plate model. (C) 2003 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:364 / 371
页数:8
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