Hydrogen peroxide sensing and signaling

被引:1304
作者
Veal, Elizabeth A. [1 ]
Day, Alison M. [1 ]
Morgan, Brian A. [1 ]
机构
[1] Newcastle Univ, Inst Cell & Mol Biosci, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
基金
英国医学研究理事会;
关键词
D O I
10.1016/j.molcel.2007.03.016
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
It is well established that oxidative stress is an important cause of cell damage associated with the initiation and progression of many diseases. Consequently, all air-living organisms contain antioxidant enzymes that limit oxidative stress by detoxifying reactive oxygen species, including hydrogen peroxide. However, in eukaryotes, hydrogen peroxide also has important roles as a signaling molecule in the regulation of a variety of biological processes. Here, we will discuss the molecular mechanisms by which hydrogen peroxide is sensed and the increasing evidence that antioxidant enzymes play multiple, key roles as sensors and regulators of signal transduction in response to hydrogen peroxide.
引用
收藏
页码:1 / 14
页数:14
相关论文
共 125 条
[61]   Cytosolic peroxiredoxin attenuates the activation of JNK and p38 but potentiates that of ERK in HeLa cells stimulated with tumor necrosis factor-α [J].
Kang, SW ;
Chang, TS ;
Lee, TH ;
Kim, ES ;
Yu, DY ;
Rhee, SG .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (04) :2535-2543
[62]   OxyR: A molecular code for redox-related signaling [J].
Kim, SO ;
Merchant, K ;
Nudelman, R ;
Beyer, WF ;
Keng, T ;
DeAngelo, J ;
Hausladen, A ;
Stamler, JS .
CELL, 2002, 109 (03) :383-396
[63]   Oxidative and electophilic stresses activate Nrf2 through inhibition of ubiquitination activity if Keap1 [J].
Kobayashi, A ;
Kang, MI ;
Watai, Y ;
Tong, KI ;
Shibata, T ;
Uchida, K ;
Yamamoto, M .
MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (01) :221-229
[64]   Regulation of thioredoxin peroxidase activity by C-terminal truncation [J].
Koo, KH ;
Lee, S ;
Jeong, SY ;
Kim, ET ;
Kim, HJ ;
Kim, K ;
Song, K ;
Chae, HZ .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2002, 397 (02) :312-318
[65]   Regulation of yAP-1 nuclear localization in response to oxidative stress [J].
Kuge, S ;
Jones, N ;
Nomoto, A .
EMBO JOURNAL, 1997, 16 (07) :1710-1720
[66]   Reactive oxygen signalling: the latest news [J].
Laloi, C ;
Apel, K ;
Danon, A .
CURRENT OPINION IN PLANT BIOLOGY, 2004, 7 (03) :323-328
[67]   Redox regulation of OxyR requires specific disulfide bond formation involving a rapid kinetic reaction path [J].
Lee, CJ ;
Lee, SM ;
Mukhopadhyay, P ;
Kim, SJ ;
Lee, SC ;
Ahn, WS ;
Yu, MH ;
Storz, G ;
Ryu, SE .
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2004, 11 (12) :1179-1185
[68]   Nrf2, a multi-organ protector? [J].
Lee, JM ;
Li, J ;
Johnson, DA ;
Stein, TD ;
Kraft, AD ;
Calkins, MJ ;
Jakel, RJ ;
Johnson, JA .
FASEB JOURNAL, 2005, 19 (09) :1061-1066
[69]   The PerR transcription factor senses H2O2 by metal-catalysed histidine oxidation [J].
Lee, JW ;
Helmann, JD .
NATURE, 2006, 440 (7082) :363-367
[70]   Reversible inactivation of the tumor suppressor PTEN by H2O2 [J].
Lee, SR ;
Yang, KS ;
Kwon, J ;
Lee, C ;
Jeong, W ;
Rhee, SG .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (23) :20336-20342