Regio- and stereoselective synthesis of 2-amino-1-hydroxy-2-aryl ethylphosphonic esters

被引：45

作者：

Cristau, HJ

Pirat, JL

Drag, M

Kafarski, P

机构：

[1] Ecole Natl Super Chim Montpellier, CNRS, UMR 5076, Chim Organ Lab, F-34296 Montpellier 5, France

[2] Univ Technol Wroclaw, Inst Organ Chem, PL-50370 Wroclaw, Poland

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 50期

关键词：

2-amino-1-hydroxy-2-aryl ethylphosphonic esters; beta-aminophosphonic esters; alpha-hydroxyphosphonic esters; ammonolysis; 1,2-epoxyphosphonic esters;

D O I：

10.1016/S0040-4039(00)01722-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly regio- and diastereoselective synthesis of 2-amino-1-hydroxy-2-aryl ethylphosphonic esters was achieved by opening trans 1,2-epoxy-2-aryl ethylphosphonic esters with 28% NH3(aq.) in methanol. (C) 2000 Published by Elsevier Science Ltd.

引用

收藏

页码：9781 / 9785

页数：5

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