The use of mitochondrial nutrients to improve the outcome of infertility treatment in older patients

During the past few decades, because Of Cultural and social changes, women in the developed world have significantly delayed childbirth (1). It is well known that pregnancy rates (PR) at age more than 35 years are significantly lower, both naturally and with assisted reproduction. The decline in live birth rate reflects a decline in response to ovarian stimulation, reduced embryo quality and PRs, and an increased incidence of miscarriages and fetal aneuploidy. At present there is no known intervention to improve the pregnancy outcome of older patients. In this article we expand on the hypothesis that mitochondrial dysfunction has a major role in reproductive senescence and propose that reproductive function in older women may be improved by the use of mitochondrial nutrients.