Gold (I)-catalyzed 5-endo-dig carbocyclization of acetylenic dicarbonyl compounds

被引:242
作者
Staben, ST [1 ]
Kennedy-Smith, JJ [1 ]
Toste, FD [1 ]
机构
[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA
关键词
C-C coupling; cyclization; cyclopentenes; dicarbonyl compounds; gold;
D O I
10.1002/anie.200460844
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Cyclopentenoid structures including compounds containing vinyl iodide, 1,3-diene, and heterocyclic moieties are obtained through the gold(I)-catalyzed 5-endo-dig addition of β-dicarbonyl compounds to unactivated alkynes under neutral conditions and at room temperature (RT). Both monocyclic and bicyclic cyclopentenes can be formed in excellent yields and with good diastereoselectivity (see scheme).
引用
收藏
页码:5350 / 5352
页数:3
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