SERS-Based Diagnosis and Biodetection

被引：377

作者：

Alvarez-Puebla, Ramon A. ^{[1
,2
]}

Liz-Marzan, Luis M. ^{[1
,2
]}

机构：

[1] Univ Vigo, CSIC, Dept Quim Fis, Vigo 36310, Spain

[2] Univ Vigo, CSIC, Unidad Asociada, Vigo 36310, Spain

来源：

SMALL | 2010年 / 6卷 / 05期

关键词：

biodetection; nanoparticles; sensing; SERS; surface plasmon resonance; SURFACE-ENHANCED RAMAN; SILVER NANOPARTICLES; SINGLE-MOLECULE; SPECTROSCOPY; SCATTERING; PARTICLES; DNA; PROTEINS; CELLS;

D O I：

10.1002/smll.200901820

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Surface-enhanced Raman scattering (SERS) spectroscopy is one of the most powerful analytical techniques for identification of molecular species, with the potential to reach single-molecule detection under ambient conditions. This Concept article presents a brief introduction and discussion of both recent advances and limitations of SERS in the context of diagnosis and biodetection, ranging from direct sensing to the use of encoded nanoparticles, in particular focusing on ultradetection of relevant bioanalytes, rapid diagnosis of diseases, marking of organelles within individual cells, and non-invasive tagging of anomalous tissues in living animals.

引用

页码：604 / 610

页数：7

共 56 条

[11] Encoding microcarriers: Present and future technologies [J].

Braeckmans, K ;

De Smedt, SC ;

Leblans, M ;

Pauwels, R ;

Demeester, J .

NATURE REVIEWS DRUG DISCOVERY, 2002, 1 (06) :447-456

[12]

Bruns OT, 2009, NAT NANOTECHNOL, V4, P193, DOI [10.1038/NNANO.2008.405, 10.1038/nnano.2008.405]

[13] Noble Metal Nanocrystals: Plasmon Electron Transfer Photochemistry and Single-Molecule Raman Spectroscopy [J].

Brus, Louis .

ACCOUNTS OF CHEMICAL RESEARCH, 2008, 41 (12) :1742-1749

[14] Nanoparticles with Raman spectroscopic fingerprints for DNA and RNA detection [J].

Cao, YWC ;

Jin, RC ;

Mirkin, CA .

SCIENCE, 2002, 297 (5586) :1536-1540

[15] Raman spectroscopy and microscopy of individual cells and cellular components [J].

Chan, James ;

Fore, Samantha ;

Wachsman-Hogiu, Sebastian ;

Huser, Thomas .

LASER & PHOTONICS REVIEWS, 2008, 2 (05) :325-349

[16] Intracellular applications of analytical SERS spectroscopy and multispectral imaging [J].

Chourpa, Igor ;

Lei, Franck H. ;

Dubois, Pierre ;

Manfait, Michel ;

Sockalingum, Ganesh D. .

CHEMICAL SOCIETY REVIEWS, 2008, 37 (05) :993-1000

[17] Molecular computational elements encode large populations of small objects [J].

De Silva, A. Prasanna ;

James, Mark R. ;

McKinney, Bernadine O. F. ;

Pears, David A. ;

Weir, Sheenagh M. .

NATURE MATERIALS, 2006, 5 (10) :787-790

[18] SERS as a foundation for nanoscale, optically detected biological labels [J].

Doering, William E. ;

Piotti, Marcelo E. ;

Natan, Michael J. ;

Freeman, R. Griffith .

ADVANCED MATERIALS, 2007, 19 (20) :3100-3108

[19] Metabolic fingerprinting as a diagnostic tool [J].

Ellis, David I. ;

Dunn, Warwick B. ;

Griffin, Julian L. ;

Allwood, J. William ;

Goodacre, Royston .

PHARMACOGENOMICS, 2007, 8 (09) :1243-1266

[20] SERS aptatags: New responsive metallic nanostructures for heterogeneous protein detection by surface enhanced Raman spectroscopy [J].

Fabris, Laura ;

Dante, Mark ;

Nguyen, Thuc-Quyen ;

Tok, Jeffrey B. -H. ;

Bazan, Guillermo C. .

ADVANCED FUNCTIONAL MATERIALS, 2008, 18 (17) :2518-2525

← 1 2 3 4 5 6 →