Th17 cells: positive or negative role in tumor?

被引：86

作者：

Ji, Yuqiang ^{[1
]}

Zhang, Wanggang ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Hosp 2, Dept Clin Hematol, Xian 710049, Peoples R China

来源：

CANCER IMMUNOLOGY IMMUNOTHERAPY | 2010年 / 59卷 / 07期

关键词：

Th17; cells; IL-17; IL-23; ROR gamma t; Tumor immunity; REGULATORY T-CELLS; GROWTH-FACTOR-BETA; ARYL-HYDROCARBON RECEPTOR; POTENT ANTITUMOR IMMUNITY; TGF-BETA; T(H)17 CELLS; CUTTING EDGE; T-H-17; CELLS; AUTOIMMUNE ENCEPHALOMYELITIS; PERIPHERAL-BLOOD;

D O I：

10.1007/s00262-010-0849-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Th17 cells have been recently identified as a distinct Th cell lineage and found in an experimental animal model of cancer and in human cancers, but whether these cells promote tumor growth or regulate antitumor responses remains controversial. This review provides a summary of the current literature regarding interleukin (IL)-17/IL-23 and Th17 cells in cancer and discusses their potential roles in cancer development. Finally, we note several issues in this research area that must be resolved before the design of novel therapeutic approaches specifically targeting Th17 cells in cancer become feasible.

引用

页码：979 / 987

页数：9

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