A Multi-Task Palladium Catalyst Involved in Heck-Reduction-Cyclization Sequences for the Preparation of 4-Benzyl-1,2-dihydroisoquinolin-3-ones: An Unusual Homogeneous-Heterogeneous Sustainable Approach

被引：21

作者：

Laudien, Julia ^{[1
]}

Fouquet, Eric ^{[1
]}

Zakri, Cecile ^{[2
]}

Felpin, Francois-Xavier ^{[1
]}

机构：

[1] Univ Bordeaux, CNRS, UMR 5255, Inst Mol Sci, F-33405 Talence, France

[2] Univ Bordeaux, CNRS, Ctr Rech Paul Pascal, F-33405 Pessac, France

来源：

SYNLETT | 2010年 / 10期

关键词：

heterogeneous catalysis; heterocycles; palladium; Heck reaction; hydrogenation; SUZUKI-MIYAURA REACTIONS; SANDMEYER REACTIONS; HRC REACTIONS; SALTS; STEPS;

D O I：

10.1055/s-0029-1219926

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mixed homogeneous-heterogeneous catalysis that exploits a multi-task palladium catalyst has been developed for one-pot sequential Heck-reduction-cyclization (HRC) reactions leading to novel 4-benzyl-1,2-dihydroisoquinolin-3-ones. The HRC sequence requires mild conditions and allows the separation of the palladium residues under the form of an in situ generated Pd(0)/C catalyst by simple filtration. The homemade and recovered catalyst can be efficiently reused for Suzuki-Miyaura reactions and reductive processes making it useful for sustainable chemistry.

引用

页码：1539 / 1543

页数：5

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