Reusable resin plug-bound palladium catalysts for organic synthesis

被引：24

作者：

Atrash, B

Reader, J

Bradley, M ^{[1
]}

机构：

[1] Univ Southampton, Dept Chem, Combinatorial Ctr Excellence, Southampton SO17 1BJ, Hants, England

[2] Millennium Pharmaceut, Cambridge CB1 6ET, England

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 25期

关键词：

resin plugs; catalysis; solid-phase synthesis; Suzuki coupling;

D O I：

10.1016/S0040-4039(03)00977-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Resin plugs, a unique and conveniently handled form of resin, prepared by sintering high-density polyethylene (HDPE) with pre-functionalised resins, were derivatised and loaded with palladium(0). These 'plugs' were used in the preparation of a Suzuki reaction based library and the removal of allyl ester protecting groups. The 'plugs of catalyst' were easily separated from the reaction mixture and were re-used multiple times with minimal loss of activity. (C) 2003 Elsevier Science Ltd. All rights reserved.

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页码：4779 / 4782

页数：4

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