MicroRNA-140 and the silencing of osteoarthritis

被引：58

作者：

Araldi, Elisa ^{[1
]}

Schipani, Ernestina ^{[1
]}

机构：

[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Endocrine Unit, Boston, MA 02114 USA

来源：

GENES & DEVELOPMENT | 2010年 / 24卷 / 11期

关键词：

MicroRNA; miR-140; osteoarthritis; cartilage; Adamts-5; JOINT FORMATION; SMALL RNAS; CARTILAGE; MATRIX; DICER; MORPHOGENESIS; DIFFERENTIATION; PROLIFERATION; DEGRADATION; BIOGENESIS;

D O I：

10.1101/gad.1939310

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

MicroRNAs (miRNAs) have emerged as important modulators in development, tissue homeostasis, and diseases. In this issue of Genes & Development, Miyaki and colleagues (pp. 1173-1185) report that miR-140 is involved in the pathogenesis of osteoarthritis by regulating, at least in part, ADAMTS5. Moreover, mice lacking miR-140 are dwarf as a consequence of impaired chondrocyte proliferation. This study is the first in vivo demonstration that miR-140 has a critical and nonredundant role in cartilage development and homeostasis.

引用

页码：1075 / 1080

页数：6

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