Estrogen protection against EAE modulates the microbiota and mucosal-associated regulatory cells

被引：50

作者：

Benedek, Gil ^{[1
,2
]}

Zhang, Jun ^{[1
,2
]}

Ha Nguyen ^{[1
,2
]}

Kent, Gail ^{[1
,2
]}

Seifert, Hilary A. ^{[1
,2
]}

Davin, Sean ^{[3
]}

Stauffer, Patrick ^{[3
]}

Vandenbark, Arthur A. ^{[1
,2
,4
]}

Karstens, Lisa ^{[5
,6
]}

Asquith, Mark ^{[3
]}

Offner, Halina ^{[1
,2
,7
]}

机构：

[1] VA Portland Hlth Care Syst, Neuroimmunol Res, R&D 31,3710 SW US Vet Hosp Rd, Portland, OR 97239 USA

[2] Oregon Hlth & Sci Univ, Dept Neurol, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA

[3] Oregon Hlth & Sci Univ, Div Arthrit & Rheumat Dis, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA

[4] Oregon Hlth & Sci Univ, Dept Mol Microbiol & Immunol, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA

[5] Oregon Hlth & Sci Univ, Div Bioinformat & Computat Biol, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA

[6] Oregon Hlth & Sci Univ, Div Urogynecol, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA

[7] Oregon Hlth & Sci Univ, Dept Anesthesiol & Perioperat Med, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2017年 / 310卷

关键词：

Estrogen; EAE; Regulatory B cell; M2-like macrophage/microglia; Microbiota; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; B-CELLS; MULTIPLE-SCLEROSIS; GUT MICROBIOME; INFLAMMATION; IL-10; MICROGLIA; THERAPY;

D O I：

10.1016/j.jneuroim.2017.06.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Sex hormones promote immunoregulatory effects on multiple sclerosis. In the current study we evaluated the composition of the gut microbiota and the mucosal-associated regulatory cells in estrogen or sham treated female mice before and after autoimmune encephalomyelitis (EAE) induction. Treatment with pregnancy levels of estrogen induces changes in the composition and diversity of gut microbiota. Additionally, estrogen prevents EAE-associated changes in the gut microbiota and might promote the enrichment of bacteria that are associated with immune regulation. Our results point to a possible cross-talk between the sex hormones and the gut microbiota, which could promote neuroprotection.

引用

页码：51 / 59

页数：9

共 59 条

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