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Forcing cells to change lineages

被引：671
作者：
Graf, Thomas [1 ,2 ]
Enver, Tariq [3 ]
机构：
[1] Ctr Genom Regulat, Barcelona 08003, Spain
[2] ICREA, Barcelona 08003, Spain
[3] John Radcliffe Hosp, MRC, Mol Haematol Unit, Weatherall Inst Mol Med, Oxford OX3 9DS, England
来源：
NATURE | 2009年 / 462卷 / 7273期
关键词：
HEMATOPOIETIC STEM-CELLS; GENE REGULATORY NETWORKS; TRANSCRIPTION FACTORS; PROGENITOR CELLS; SELF-RENEWAL; IN-VIVO; HAEMOGENIC ENDOTHELIUM; INDUCED PLURIPOTENCY; CHROMATIN-STRUCTURE; C/EBP-ALPHA;
D O I：
10.1038/nature08533
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The ability to produce stem cells by induced pluripotency (iPS reprogramming) has rekindled an interest in earlier studies showing that transcription factors can directly convert specialized cells from one lineage to another. Lineage reprogramming has become a powerful tool to study cell fate choice during differentiation, akin to inducing mutations for the discovery of gene functions. The lessons learnt provide a rubric for how cells may be manipulated for therapeutic purposes.
引用
收藏
页码：587 / 594
页数：8
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